The CENPO Polyclonal Antibody (PACO08366) is a valuable tool for researchers studying the centromere protein C (CENPO), a critical component of the centromere complex involved in proper chromosome segregation during cell division. This antibody, derived from rabbit immunization, exhibits high specificity and sensitivity for detecting CENPO in human samples.CENPO plays a crucial role in maintaining chromosomal stability and ensuring accurate distribution of genetic material during cell division. Dysregulation of CENPO has been linked to chromosomal instability and cancer development, making it a promising target for cancer research and potential therapeutic interventions.
With its validated application in Western blotting, the CENPO Polyclonal Antibody enables researchers to visualize and analyze CENPO expression in various cell types and tissue samples. Its reliability and consistency make it an essential tool for studies exploring the role of CENPO in cell cycle regulation, chromosome segregation, and diseases such as cancer.
CENPO: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 2p23.3Cellular Component: cytosol; nucleoplasmMolecular Function: protein bindingBiological Process: DNA replication-independent nucleosome assembly at centromere; sister chromatid cohesion
UniProt Protein Details:
NCBI Summary:
This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
