The CENPL Polyclonal Antibody (PACO08365) is a valuable tool for researchers studying the centromere protein L (CENPL), a key player in chromosome segregation during cell division. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CENPL protein, researchers can accurately detect and analyze its expression in a variety of cell types.CENPL is essential for proper chromosome segregation during mitosis and its dysregulation can lead to genomic instability and potentially contribute to tumorigenesis.
As such, the CENPL Polyclonal Antibody is an invaluable resource for investigations into cancer biology and cell division processes. By gaining a better understanding of CENPL function, researchers may uncover new therapeutic targets for cancer treatment or develop diagnostic tools for monitoring chromosomal abnormalities.
centromere protein L;CENPL;C1orf155;CENP-L;FLJ31044;FLJ31786;RP3-383J4.1;dJ383J4.3 ;
UniProt Protein Function:
CENPL: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 1q25.1Cellular Component: nucleoplasm; cytosol; chromosome, pericentric regionBiological Process: nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle
UniProt Protein Details:
NCBI Summary:
CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]
