CENPE Rabbit Polyclonal Antibody (CAB15263)
- SKU:
- CAB15263
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | CENPE Rabbit Polyclonal Antibody |
SKU: | CAB15263 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2542-2701 of human CENPE (NP_001804.2). |
Sequence: | ALIL KSEH IRLE KEIS KLKQ QNEQ LIKQ KNEL LSNN QHLS NEVK TWKE RTLK REAH KQVT CENS PKSP KVTG TASK KKQI TPSQ CKER NLQD PVPK ESPK SCFF DSRS KSLP SPHP VRYF DNSS LGLC PEVQ NAGA ESVD SQPG PWHA SSGK DVPE CKTQ |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | KIF10; CENP-E; MCPH13; PPP1R61; CENPE |
Positive Sample: | U-87MG,HeLa,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Cytoplasm, centromere, cytoskeleton, kinetochore, spindle. |
Calculated MW: | 316kDa |
Observed MW: | 270kDa |
Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.
Purification Method: | Affinity purification |
Gene ID: | 1062 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |