The CENPC Polyclonal Antibody (CAB6557) is a valuable tool for researchers studying the centromere protein C (CENPC), a key player in chromosome segregation and cell division. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the CENPC protein, researchers can easily detect and analyze this critical protein in a variety of cell types.CENPC is essential for proper chromosome alignment and segregation during cell division, making it a crucial target for studying cancer biology and genetic disorders.
Dysregulation of CENPC has been linked to chromosomal instability and tumorigenesis, highlighting its importance in maintaining genomic stability. By investigating the function of CENPC using this antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.
Product Name:
CENPC Rabbit Polyclonal Antibody
SKU:
CAB6557
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CENPC (NP_001803.2).
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.
Purification Method:
Affinity purification
Gene ID:
1060
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CENPC antibody (CAB6557) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
