CENPB Rabbit Polyclonal Antibody (CAB16817)
- SKU:
- CAB16817
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | CENPB Rabbit Polyclonal Antibody |
SKU: | CAB16817 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human CENPB (NP_001801.1). |
Sequence: | TLHF LEGG EDSD SDSE EEDD EEED DEDE DDDD DEED GDEV PVPS FGEA MAYF AMVK RYLT SFPI DDRV QSHI LHLE HDLV HVTR KNHA RQAG VRGL GHQS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CENPB |
Positive Sample: | Mouse liver,Rat liver |
Cellular Localization: | nuclear body, nucleoplasm, nucleus |
Calculated MW: | 65kDa |
Observed MW: | 72kDa |
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
Purification Method: | Affinity purification |
Gene ID: | 1059 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |