The CELSR3 Polyclonal Antibody (PAC062783) is a crucial tool for researchers studying CELSR3, a member of the cadherin superfamily implicated in various cellular processes, particularly in neural development. This antibody, generated in rabbits, exhibits high reactivity with human and mouse samples, and has been validated for use in immunohistochemistry and Western blot applications. Its specificity in binding to the CELSR3 protein enables precise detection and analysis in a range of cell types, making it an essential reagent for investigations in neuroscience and developmental biology.CELSR3, also known as Flamingo homolog 3, plays a vital role in neuronal migration, axon guidance, and synapse formation in the developing brain.
Its involvement in these processes underscores its importance in neurodevelopmental disorders and neurological diseases. By targeting CELSR3, researchers can gain valuable insights into the mechanisms underlying neural circuit formation and function, paving the way for potential therapeutic interventions in conditions such as autism, schizophrenia, and epilepsy.Investigating the function of CELSR3 with the PAC062783 antibody is crucial for advancing our understanding of brain development and neurological disorders, ultimately leading to new therapeutic strategies and treatments.
Antibody Name:
CELSR3 Antibody (PACO62783)
Antibody SKU:
PACO62783
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 3 protein (514-718AA)
IHC image of PACO62783 diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Receptor that may have an important role in cell/cell signaling during nervous system formation.
Synonyms:
Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2), CELSR3, CDHF11 EGFL1 FMI1 KIAA0812 MEGF2
UniProt Protein Function:
CELSR3: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCRChromosomal Location of Human Ortholog: 3p21.31Cellular Component: plasma membrane; integral to membraneMolecular Function: G-protein coupled receptor activity; protein binding; calcium ion bindingBiological Process: G-protein coupled receptor protein signaling pathway; regulation of protein localization; neuron migration; axonal fasciculation; cilium biogenesis; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
Predicted Molecular Mass: 29.6kDaAccurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions.
NCBI Full Name:
cadherin EGF LAG seven-pass G-type receptor 3
NCBI Synonym Full Names:
cadherin, EGF LAG seven-pass G-type receptor 3
NCBI Official Symbol:
CELSR3Â Â
NCBI Official Synonym Symbols:
FMI1; EGFL1; HFMI1; MEGF2; ADGRC3; CDHF11; RESDA1Â Â
NCBI Protein Information:
cadherin EGF LAG seven-pass G-type receptor 3
UniProt Protein Name:
Cadherin EGF LAG seven-pass G-type receptor 3
UniProt Synonym Protein Names:
Cadherin family member 11; Epidermal growth factor-like protein 1; EGF-like protein 1; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains protein 2; Multiple EGF-like domains protein 2
