The Celsr3 Antibody (PAC023311) is a high-quality research tool designed for studying the Celsr3 protein, which plays a crucial role in cell signaling and development. This polyclonal antibody, generated in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications.Celsr3 is a key regulator of cell polarity and tissue organization, making it a valuable target for research in developmental biology and neurobiology. Its involvement in neural tube formation and neural crest migration makes it particularly relevant for studies on central nervous system development and related disorders.
By targeting the Celsr3 protein, researchers can gain insights into the molecular mechanisms underlying neuronal development and axon guidance. This antibody enables the detection and analysis of Celsr3 expression in various cell types, providing valuable information for understanding its role in development and disease.Overall, the Celsr3 Antibody is a reliable tool for investigating the functions and mechanisms of the Celsr3 protein, offering new opportunities for advancing our knowledge of cell signaling pathways and developmental processes.
CELSR3: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCRChromosomal Location of Human Ortholog: 3p21.31Cellular Component: plasma membrane; integral to membraneMolecular Function: G-protein coupled receptor activity; protein binding; calcium ion bindingBiological Process: G-protein coupled receptor protein signaling pathway; regulation of protein localization; neuron migration; axonal fasciculation; cilium biogenesis; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
Predicted Molecular Mass: 29.6kDaAccurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions.
NCBI Full Name:
cadherin EGF LAG seven-pass G-type receptor 3
NCBI Synonym Full Names:
cadherin, EGF LAG seven-pass G-type receptor 3
NCBI Official Symbol:
CELSR3Â Â
NCBI Official Synonym Symbols:
FMI1; EGFL1; HFMI1; MEGF2; ADGRC3; CDHF11; RESDA1Â Â
NCBI Protein Information:
cadherin EGF LAG seven-pass G-type receptor 3
UniProt Protein Name:
Cadherin EGF LAG seven-pass G-type receptor 3
UniProt Synonym Protein Names:
Cadherin family member 11; Epidermal growth factor-like protein 1; EGF-like protein 1; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains protein 2; Multiple EGF-like domains protein 2
