| UniProt Protein Function: | CELSR3: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCRChromosomal Location of Human Ortholog: 3p21.31Cellular Component: plasma membrane; integral to membraneMolecular Function: G-protein coupled receptor activity; protein binding; calcium ion bindingBiological Process: G-protein coupled receptor protein signaling pathway; regulation of protein localization; neuron migration; axonal fasciculation; cilium biogenesis; homophilic cell adhesion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q9NYQ7 |
| NCBI GenInfo Identifier: | 145309304 |
| NCBI Gene ID: | 1951 |
| NCBI Accession: | NP_001398.2 |
| UniProt Secondary Accession: | Q9NYQ7,O75092 |
| UniProt Related Accession: | Q9NYQ7 |
| Molecular Weight: | Predicted Molecular Mass: 29.6kDaAccurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions. |
| NCBI Full Name: | cadherin EGF LAG seven-pass G-type receptor 3 |
| NCBI Synonym Full Names: | cadherin, EGF LAG seven-pass G-type receptor 3 |
| NCBI Official Symbol: | CELSR3Â Â |
| NCBI Official Synonym Symbols: | FMI1; EGFL1; HFMI1; MEGF2; ADGRC3; CDHF11; RESDA1Â Â |
| NCBI Protein Information: | cadherin EGF LAG seven-pass G-type receptor 3 |
| UniProt Protein Name: | Cadherin EGF LAG seven-pass G-type receptor 3 |
| UniProt Synonym Protein Names: | Cadherin family member 11; Epidermal growth factor-like protein 1; EGF-like protein 1; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains protein 2; Multiple EGF-like domains protein 2 |
| Protein Family: | Cadherin EGF LAG seven-pass G-type receptor |
| UniProt Gene Name: | CELSR3Â Â |
| UniProt Entry Name: | CELR3_HUMAN |
