The CELF6 Polyclonal Antibody (CAB17748) is a valuable tool for researchers studying CELF6, a member of the CELF family of RNA-binding proteins involved in RNA metabolism and alternative splicing. This rabbit polyclonal antibody is highly specific to CELF6 and has been validated for use in Western blot applications. By targeting the CELF6 protein, this antibody enables researchers to detect and analyze CELF6 expression in various cell types, making it a versatile tool for investigations in molecular biology and gene regulation.CELF6, also known as CUGBP Elav-like family member 6, plays a crucial role in post-transcriptional regulation of gene expression, impacting processes such as mRNA stability and translation.
Its involvement in alternative splicing and RNA processing makes it a key player in controlling gene expression patterns, with implications for various cellular functions. Studying CELF6 is important for understanding its impact on RNA biology and its potential implications in diseases such as muscular dystrophy and neurological disorders.Overall, the CELF6 Polyclonal Antibody is an essential resource for researchers interested in unraveling the molecular mechanisms underlying gene expression regulation and RNA processing, with potential applications in fields such as developmental biology, neurology, and genetic disorders.
Product Name:
CELF6 Rabbit Polyclonal Antibody
SKU:
CAB17748
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 230-380 of human CELF6 (NP_443072.3).
Mouse brain,Mouse testis,Mouse large intestine,Rat testis
Conjugate:
Unconjugated
Cellular Localization:
cytoplasm, nucleus
Calculated MW:
50kDa
Observed MW:
51kDa
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Purification Method:
Affinity purification
Gene ID:
60677
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CELF6 Rabbit pAb (CAB17748) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
