UniProt Protein Function: | CELF4: RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Belongs to the CELF/BRUNOL family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: RNA splicingChromosomal Location of Human Ortholog: 18q12Cellular Component: cytoplasm; nucleusMolecular Function: mRNA binding; BRE binding; translation repressor activity, nucleic acid binding; nucleotide bindingBiological Process: positive regulation of nuclear mRNA splicing, via spliceosome; alternative nuclear mRNA splicing, via spliceosome; mRNA splice site selection; embryonic development; negative regulation of nuclear mRNA splicing, via spliceosome; negative regulation of translation; regulation of alternative nuclear mRNA splicing, via spliceosome; germ cell development |
UniProt Protein Details: | |
NCBI Summary: | Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BZC1 |
NCBI GenInfo Identifier: | 187761299 |
NCBI Gene ID: | 56853 |
NCBI Accession: | NP_001020258.1 |
UniProt Secondary Accession: | Q9BZC1,Q59EN7, Q86XB9, Q8N2M6, Q9BQ96, Q9NR84, Q9NR85 |
UniProt Related Accession: | Q9BZC1 |
Molecular Weight: | 47,727 Da |
NCBI Full Name: | CUGBP Elav-like family member 4 isoform 2 |
NCBI Synonym Full Names: | CUGBP, Elav-like family member 4 |
NCBI Official Symbol: | CELF4Â Â |
NCBI Official Synonym Symbols: | BRUNOL4; BRUNOL-4Â Â |
NCBI Protein Information: | CUGBP Elav-like family member 4 |
UniProt Protein Name: | CUGBP Elav-like family member 4 |
UniProt Synonym Protein Names: | Bruno-like protein 4; CUG-BP- and ETR-3-like factor 4; RNA-binding protein BRUNOL-4 |
Protein Family: | CUGBP Elav-like family |
UniProt Gene Name: | CELF4Â Â |
UniProt Entry Name: | CELF4_HUMAN |