The CELF2 Polyclonal Antibody (CAB6016) is an essential tool for researchers studying CELF2, a RNA-binding protein that plays a key role in post-transcriptional regulation of gene expression. This antibody, produced in rabbits, specifically targets CELF2 and is highly reactive with human samples. Validated for use in Western blot applications, it enables accurate detection and analysis of CELF2 protein levels in various cell types.CELF2 is known to regulate alternative splicing, mRNA stability, and translation, impacting a wide range of cellular processes such as cell growth, differentiation, and apoptosis. Dysregulation of CELF2 expression has been linked to various diseases including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.
Therefore, research involving CELF2 and its functions is crucial for understanding disease mechanisms and developing effective treatments.By using the CELF2 Polyclonal Antibody, researchers can gain valuable insights into the role of CELF2 in cellular processes and diseases, advancing our knowledge of RNA biology and potentially leading to the development of novel therapeutics. This antibody is a valuable tool for studies in molecular biology, cancer research, and neuroscience, providing researchers with a reliable means of investigating the complex functions of CELF2.
Product Name:
CELF2 Rabbit Polyclonal Antibody
SKU:
CAB6016
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 422-521 of human CELF2 (NP_006552.3).
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10659
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CELF2 antibody (CAB6016) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
