The CELA3B Polyclonal Antibody (CAB13714) is a vital tool for researchers studying CELA3B, a chymotrypsin-like elastase family member B involved in proteolytic degradation and tissue remodeling. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for a variety of applications such as Western blot and immunohistochemistry.CEL3B is known for its role in the degradation of extracellular matrix proteins, as well as its involvement in inflammatory processes and tissue repair mechanisms.
Dysregulation of CELA3B expression has been linked to various diseases, including cancer, chronic obstructive pulmonary disease (COPD), and inflammatory disorders. Researchers can utilize this antibody to investigate the role of CELA3B in these pathologies and potentially identify new therapeutic targets for intervention.
Product Name:
CELA3B Rabbit Polyclonal Antibody
SKU:
CAB13714
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 80-190 of human CELA3B (NP_031378.1).
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
Purification Method:
Affinity purification
Gene ID:
23436
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat pancreas, using CELA3B Rabbit pAb (CAB13714) at 1:3000 dilution.