CELA3A Antibody (PACO26445)
- SKU:
- PACO26445
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CELA3A Antibody (PACO26445)
The CELA3A Polyclonal Antibody (PAC026445) is a valuable tool for researchers studying CELA3A, a key protease enzyme involved in digestion and other physiological processes. Produced in rabbits, this antibody exhibits high reactivity with human CELA3A samples and has been validated for use in Western blot applications. By specifically binding to the CELA3A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for research in the fields of biology, biochemistry, and gastroenterology.
CELA3A, also known as chymotrypsin-like elastase family member 3A, plays a crucial role in the breakdown of proteins in the digestive system. Dysregulation of CELA3A has been linked to various digestive disorders, making it a promising target for therapeutic interventions. By studying the function and regulation of CELA3A, researchers can gain insights into digestive diseases and potentially develop novel treatments to improve patient outcomes.
| Antibody Name: | CELA3A Antibody (PACO26445) |
| Antibody SKU: | PACO26445 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Chymotrypsin-like elastase family member 3A protein (29-270AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: CELA3A antibody at 14µg/ml Lane 1: Mouse heart tissue Lane 2: Mouse skeletal muscle tissue Lane 3: Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 30 kDa Observed band size: 30 kDa . |
| Background: | Efficient protease with alanine specificity but only little elastolytic activity. |
| Synonyms: | Chymotrypsin-like elastase family member 3A (EC 3.4.21.70) (Elastase IIIA) (Elastase-3A) (Protease E), CELA3A, ELA3 ELA3A |
| UniProt Protein Function: | CELA3A: Efficient protease with alanine specificity but only little elastolytic activity. Belongs to the peptidase S1 family. Elastase subfamily.Protein type: Protease; EC 3.4.21.70Chromosomal Location of Human Ortholog: 1p36.12Cellular Component: extracellular spaceBiological Process: cholesterol metabolic process; digestion |
| UniProt Protein Details: | |
| NCBI Summary: | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09093 |
| NCBI GenInfo Identifier: | 288558842 |
| NCBI Gene ID: | 10136 |
| NCBI Accession: | P09093.3 |
| UniProt Secondary Accession: | P09093,Q9BRW4, B1AQ53 |
| UniProt Related Accession: | P09093 |
| Molecular Weight: | 29,489 Da |
| NCBI Full Name: | Chymotrypsin-like elastase family member 3A |
| NCBI Synonym Full Names: | chymotrypsin like elastase family member 3A |
| NCBI Official Symbol: | CELA3AÂ Â |
| NCBI Official Synonym Symbols: | ELA3; ELA3AÂ Â |
| NCBI Protein Information: | chymotrypsin-like elastase family member 3A |
| UniProt Protein Name: | Chymotrypsin-like elastase family member 3A |
| UniProt Synonym Protein Names: | Elastase IIIA; Elastase-3A; Protease E |
| Protein Family: | Chymotrypsin-like elastase family |
| UniProt Gene Name: | CELA3AÂ Â |
| UniProt Entry Name: | CEL3A_HUMAN |
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