The CEL Polyclonal Antibody (CAB13011) is a valuable tool for researchers studying CEL, a protein associated with immune regulation and inflammatory responses. This antibody, produced in rabbits, is highly specific to CEL in human samples and is suitable for use in Western blot applications. By binding to the CEL protein, this antibody allows for precise detection and analysis in various cell types, making it an essential reagent for studies in immunology and cancer research.CEL, also known as carboxyl ester lipase, plays a crucial role in lipid metabolism and digestion by catalyzing the hydrolysis of dietary fats.
In addition, CEL has been implicated in various disease processes, including pancreatitis and inflammatory bowel disease. Research into the function and regulation of CEL is essential for understanding its role in these conditions and may lead to the development of novel therapeutic approaches targeting CEL.Overall, the CEL Polyclonal Antibody (CAB13011) is a valuable tool for researchers investigating the role of CEL in immune regulation, inflammation, and metabolic disorders. Its high specificity and reactivity make it a reliable reagent for studying CEL in both basic and translational research settings.
Product Name:
CEL Rabbit Polyclonal Antibody
SKU:
CAB13011
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-550 of human CEL (NP_001798.2).
BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8; CEL
Positive Sample:
Mouse pancreas
Conjugate:
Unconjugated
Cellular Localization:
Secreted.
Calculated MW:
79kDa
Observed MW:
67kDa
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein.
Purification Method:
Affinity purification
Gene ID:
1056
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse pancreas, using CEL Rabbit pAb (CAB13011) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
