The CEBPA Polyclonal Antibody (CAB0904) is developed for research targeting CEBPA, a vital transcription factor involved in the regulation of gene expression in various cellular processes. This antibody, produced in rabbits, exhibits high specificity for human samples and has been extensively validated for Western blot applications. By binding to the CEBPA protein, researchers can accurately detect and analyze CEBPA expression in different cell types, making it a valuable tool for studies in molecular biology and cancer research.
CEBPA plays a crucial role in the control of cell growth and differentiation, making it a key player in the development and progression of various diseases, including cancer. By investigating the functions of CEBPA, scientists can gain insights into potential therapeutic targets for cancer treatment and other genetic disorders. The CEBPA Polyclonal Antibody provides a reliable means of studying CEBPA activity, paving the way for advancements in personalized medicine and precision oncology.
Product Name:
CEBPA Rabbit Polyclonal Antibody
SKU:
CAB0904
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 111-180 of human CEBPA (NP_004355.2).
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons.
Purification Method:
Affinity purification
Gene ID:
1050
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CEBPA Rabbit pAb (CAB0904) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
