CEACAM3/CEACAM6 Antibody (PACO06892)
- SKU:
- PACO06892
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CEACAM3/CEACAM6 Antibody (PACO06892)
The CEACAM3/CEACAM6 Antibody (PACO06892) is a valuable tool for researchers studying CEACAM3 and CEACAM6 proteins, which are cell adhesion molecules involved in various cellular processes. This polyclonal antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.CEACAM3 and CEACAM6 are members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family, and are known to play important roles in immune response regulation, cell signaling, and tumorigenesis. By using this antibody, researchers can effectively detect and analyze CEACAM3 and CEACAM6 proteins in different cell types, providing critical insights into their functions in immunology and cancer research.
The CEACAM3/CEACAM6 Antibody is an essential tool for investigating the involvement of these proteins in various diseases, including cancer and inflammatory conditions. Understanding the molecular mechanisms of CEACAM3 and CEACAM6 can lead to the development of novel therapeutic strategies targeting these proteins, making this antibody a valuable resource for advancing biomedical research.
| Antibody Name: | CEACAM3/CEACAM6 Antibody (PACO06892) |
| Antibody SKU: | PACO06892 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from the Internal region of human CD66c/d. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of HepG2 mouse brain cells using CD66c/d Polyclonal Antibody. |
 | Western Blot analysis of HEPG2 cells using CD66c/d Polyclonal Antibody. |
| Synonyms: | CEACAM3; CD66D; CGM1; Carcinoembryonic antigen-related cell adhesion molecule 3; Carcinoembryonic antigen CGM1; CD66d; CEACAM6; NCA; Carcinoembryonic antigen-related cell adhesion molecule 6; Non-specific crossreacting antigen; Normal cross-reacting antig |
| UniProt Protein Function: | CEACAM3: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation. CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. Belongs to the immunoglobulin superfamily. CEA family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: integral to membrane |
| NCBI Summary: | This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013] |
| UniProt Code: | P40198 |
| NCBI GenInfo Identifier: | 218511974 |
| NCBI Gene ID: | 1084 |
| NCBI Accession: | P40198.2 |
| UniProt Related Accession: | P40198 |
| Molecular Weight: | |
| NCBI Full Name: | Carcinoembryonic antigen-related cell adhesion molecule 3 |
| NCBI Synonym Full Names: | carcinoembryonic antigen related cell adhesion molecule 3 |
| NCBI Official Symbol: | CEACAM3Â Â |
| NCBI Official Synonym Symbols: | CEA; CGM1; W264; W282; CD66DÂ Â |
| NCBI Protein Information: | carcinoembryonic antigen-related cell adhesion molecule 3 |
| UniProt Protein Name: | Carcinoembryonic antigen-related cell adhesion molecule 3 |
| UniProt Synonym Protein Names: | Carcinoembryonic antigen CGM1; CD_antigen: CD66d |
| UniProt Gene Name: | CEACAM3Â Â |
| UniProt Entry Name: | CEAM3_HUMAN |
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