The CEACAM16 Antibody (PAC057696) is a powerful tool for researchers studying CEACAM16, a cell adhesion molecule involved in various biological processes. This polyclonal antibody, generated in rabbits, exhibits high specificity and sensitivity towards CEACAM16 in human samples, making it suitable for Western blot applications.CEACAM16, a member of the carcinoembryonic antigen-related cell adhesion molecule family, is known to play a role in cell adhesion, migration, and signaling. Its expression has been implicated in cancer progression, particularly in metastasis and tumor growth.
By targeting CEACAM16 with this antibody, researchers can investigate its function in different cell types and explore its potential as a therapeutic target in cancer research.The CEACAM16 Antibody (PAC057696) is a valuable tool for scientists seeking to unravel the complexities of CEACAM16 biology and its implications in health and disease. Its reliability and versatility make it an essential reagent for studies in cell adhesion, cancer biology, and other fields related to CEACAM16-mediated pathways.
Antibody Name:
CEACAM16 Antibody (PACO57696)
Antibody SKU:
PACO57696
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:500-1:1000
Species Reactivity:
Human
Immunogen:
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 16 protein (323-414AA)
IHC image of PACO57696 diluted at 1:500 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.
CEACAM16: May play a role in maintaining the integrity of the tectorial membrane. Defects in CEACAM16 are the cause of deafness autosomal dominant type 4B (DFNA4B). A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the immunoglobulin superfamily. CEA family.Protein type: Secreted, signal peptide; Immunoglobulin superfamily; Membrane protein, integral; SecretedChromosomal Location of Human Ortholog: 19q13.32Cellular Component: extracellular region; stereocilium bundle tipBiological Process: sensory perception of soundDisease: Deafness, Autosomal Dominant 4b
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]
