The CEACAM1 Rabbit Monoclonal Antibody is a cutting-edge tool for researchers studying CEACAM1, a transmembrane glycoprotein involved in cell adhesion and signaling. This high-quality antibody, generated in rabbits, demonstrates exceptional reactivity with human samples and is ideal for use in various applications, including Western blotting and immunohistochemistry.CEACAM1, also known as carcinoembryonic antigen-related cell adhesion molecule 1, plays a crucial role in cell-cell interactions, immune regulation, and tumor suppression. Its diverse functions make it a key player in cancer research, immunology, and inflammation studies. By targeting CEACAM1 with this specific antibody, researchers can accurately detect and analyze the protein in different cell types, providing invaluable insights into its roles in health and disease.
The CEACAM1 Rabbit Monoclonal Antibody is a valuable tool for investigating the mechanisms underlying CEACAM1-mediated processes, paving the way for the development of novel therapeutic strategies for cancer, autoimmune disorders, and other immune-related conditions. Its high specificity and sensitivity make it an indispensable asset for researchers seeking to advance our understanding of CEACAM1 biology and its implications in human health.
Product Name:
CEACAM1 Rabbit Monoclonal Antibody
SKU:
CAB11626
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 427-526 of human CEACAM1 (P13688).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
58kDa
Observed MW:
150kDa
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
Purification Method:
Affinity purification
Gene ID:
634
Clone Number:
ARC0649
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using CEACAM1 Rabbit mAb (CAB11626) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
