The CEACAM1 Polyclonal Antibody (CAB1702) is a valuable tool for researchers studying CEACAM1, a cell adhesion molecule with important roles in immune regulation and tumor suppression. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications.CEACAM1, also known as carcinoembryonic antigen-related cell adhesion molecule 1, is involved in cell signaling pathways that regulate immune responses and inhibit tumor growth. Its expression levels have been linked to various cancers, including colorectal, lung, and pancreatic cancer, making it a promising target for cancer research and therapy development.
By targeting the CEACAM1 protein, this polyclonal antibody enables accurate detection and analysis of CEACAM1 in different cell types, allowing researchers to further investigate its roles in immunology and cancer biology. Understanding the functions of CEACAM1 is essential for developing novel approaches to treat cancer and other diseases related to immune dysregulation.
Product Name:
CEACAM1 Rabbit Polyclonal Antibody
SKU:
CAB1702
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-430 of human CEACAM1 (NP_001703.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
58kDa
Observed MW:
130kDa/150kDa
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
Purification Method:
Affinity purification
Gene ID:
634
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using CEACAM1 Rabbit pAb (CAB1702) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
