The CDYL Polyclonal Antibody (CAB6258) is a valuable tool for researchers studying the CDYL protein, a key regulator of chromatin remodeling and gene expression. This antibody, generated in rabbits, has high specificity for human samples and is validated for use in Western blot applications.CDYL, also known as chromodomain Y-like protein, plays a crucial role in gene regulation by interacting with histone proteins and controlling chromatin structure. Its involvement in epigenetic regulation makes it a target of interest in studies on development, cellular differentiation, and diseases such as cancer.
By binding to the CDYL protein, this antibody enables detection and analysis of CDYL expression in various cell types, making it an essential tool for research in the fields of epigenetics, developmental biology, and oncology. Understanding the function of CDYL can provide insights into the mechanisms underlying gene regulation and potentially lead to the development of novel therapeutic strategies targeting epigenetic pathways.
Product Name:
CDYL Rabbit Polyclonal Antibody
SKU:
CAB6258
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 245-544 of human CDYL (NP_004815.3).
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene.
Purification Method:
Affinity purification
Gene ID:
9425
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of U-251MG cells, using CDYL antibody (CAB6258) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
