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Anti-CDX2 Antibody (CAB16816)

SKU:
CAB16816
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€129
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Description

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Anti-CDX2 Antibody (CAB16816)

The CDX2 Rabbit Polyclonal Antibody (CAB16816) is a highly specific and sensitive tool for research involving the CDX2 protein, a transcription factor essential for intestinal development and differentiation. This antibody, produced in rabbits, is suitable for use in various applications, including immunohistochemistry, immunofluorescence, and Western blotting.CDX2 is a crucial factor in maintaining normal intestinal epithelial cell function and has been implicated in gastrointestinal diseases and cancers. By targeting the CDX2 protein, researchers can gain insights into the mechanisms underlying intestinal homeostasis and pathology.

The high specificity and sensitivity of the CAB16816 antibody make it an ideal choice for studies in gastrointestinal biology, cancer research, and developmental biology.Overall, the CDX2 Rabbit Polyclonal Antibody (CAB16816) offers researchers a reliable tool to investigate the role of CDX2 in various biological processes and diseases, providing valuable insights into potential therapeutic targets and strategies for gastrointestinal disorders and cancer treatment.

Antibody Name:Anti-CDX2 Antibody
Antibody SKU:CAB16816
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human CDX2 (NP_001256.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human CDX2 (NP_001256.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MYVS YLLD KDVS MYPS SVRH SGGL NLAP QNFV SPPQ YPDY GGYH VAAA AAAA ANLD SAQS PGPS WPAA YGAP LRED WNGY APGG AAAA ANAV AHGL NGGS PAAA MGYS SPAD YHPH HHPH HHPH HPAA APSC ASGL LQTL NPGP PGPA ATAA AEQL SPGG QRRN LCEW MRKP AQQS LGSQ
Gene ID:1045
Uniprot:Q99626
Cellular Location:
Calculated MW:33kDa
Observed MW:Refer to figures
Synonyms:CDX2, CDX-3, CDX2/AS, CDX3
Background:This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
UniProt Protein Function:CDX2: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Belongs to the Caudal homeobox family.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; nucleus

Molecular Function:transcription factor activity

Biological Process: anterior/posterior axis specification; cell differentiation; negative regulation of transcription from RNA polymerase II promoter; organ morphogenesis; regulation of somitogenesis; transcription from RNA polymerase II promoter

NCBI Summary:This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
UniProt Code:Q99626
NCBI GenInfo Identifier:311033469
NCBI Gene ID:1045
NCBI Accession:Q99626.3
UniProt Secondary Accession:Q99626,O00503, Q5VTU7, Q969L8, Q9UD92,
UniProt Related Accession:Q99626
Molecular Weight:33,520 Da
NCBI Full Name:Homeobox protein CDX-2
NCBI Synonym Full Names:caudal type homeobox 2
NCBI Official Symbol:CDX2  
NCBI Official Synonym Symbols:CDX3; CDX-3; CDX2/AS  
NCBI Protein Information:homeobox protein CDX-2
UniProt Protein Name:Homeobox protein CDX-2
UniProt Synonym Protein Names:CDX-3; Caudal-type homeobox protein 2
Protein Family:Homeobox protein
UniProt Gene Name:CDX2  
UniProt Entry Name:CDX2_HUMAN

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