The CDKN3 Polyclonal Antibody (CAB2061) is specifically designed for research involving CDKN3, a protein involved in cell cycle regulation and cancer development. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the CDKN3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal tool for studies in cell biology and cancer research.CDKN3 plays a crucial role in regulating cell division and promoting cell proliferation, making it a key player in the development and progression of cancer.
Understanding the function and expression of CDKN3 is essential for identifying potential therapeutic targets and biomarkers for cancer therapy. This antibody provides researchers with a valuable tool for investigating the role of CDKN3 in various cellular processes, ultimately advancing our understanding of cancer biology and potentially leading to new treatment strategies.
Product Name:
CDKN3 Rabbit Polyclonal Antibody
SKU:
CAB2061
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-69 of human CDKN3 (NP_005183.2).
Sequence:
MKPP SSIQ TSEF DSSD EEPI EDEQ TPIH ISWL SLSR VNCS QFLG LCAL PGCK FKDV RRNV QKDT EELK S
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1033
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from MCF7 cells, using CDKN3 Rabbit pAb (CAB2061) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
