CDKN2C/p18-INK4C Rabbit Monoclonal Antibody (CAB8751)
- SKU:
- CAB8751
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | CDKN2C/p18-INK4C Rabbit Monoclonal Antibody |
SKU: | CAB8751 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human CDKN2C/p18-INK4C (P42773). |
Sequence: | MAEP WGNE LASA AARG DLEQ LTSL LQNN VNVN AQNG FGRT ALQV MKLG NPEI ARRL LLRG ANPD LKDR TGFA VIHD AARA GFLD TLQT LLEF QADV NIED NEGN LPLH LAAK EGHL RVVE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | p18; INK4C; p18-INK4C; 4C |
Positive Sample: | HeLa,293T,NIH/3T3,Mouse lung,Mouse testis,Rat spleen,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, nucleus |
Calculated MW: | 18kDa |
Observed MW: | 17kDa |
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
Purification Method: | Affinity purification |
Gene ID: | 1031 |
Clone Number: | ARC1289 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |