The CDKN2C (p18-INK4C) Polyclonal Antibody is a valuable tool for studying the CDKN2C protein, a tumor suppressor gene that plays a role in cell cycle regulation and inhibition of cell proliferation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in various applications such as Western blotting. By targeting the CDKN2C protein, researchers can detect and analyze its expression in different cell types, making it an essential tool for cancer research and understanding cell cycle control mechanisms.CDKN2C, also known as p18-INK4C, is involved in controlling cell growth and preventing the development of tumors by inhibiting the activity of cyclin-dependent kinases.
Dysregulation of CDKN2C can lead to uncontrolled cell proliferation and contribute to the progression of various types of cancer. Therefore, studying the expression and function of CDKN2C is crucial for identifying potential targets for cancer therapy and developing strategies to inhibit tumor growth. Overall, the CDKN2C (p18-INK4C) Polyclonal Antibody is a valuable resource for researchers interested in studying the molecular mechanisms of cell cycle regulation, tumor suppression, and potential therapeutic targets for cancer treatment.
Product Name:
CDKN2C/p18-INK4C Polyclonal Antibody
SKU:
CAB21326
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human CDKN2C/p18-INK4C (NP_523240.1).
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
Purification Method:
Affinity purification
Gene ID:
1031
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CDKN2C/p18-INK4C Rabbit pAb (CAB21326) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
