CDKN2B Rabbit Polyclonal Antibody (CAB5685)
- SKU:
- CAB5685
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | CDKN2B Rabbit Polyclonal Antibody |
SKU: | CAB5685 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-138 of human CDKN2B (NP_004927.2). |
Sequence: | MREE NKGM PSGG GSDE GLAS AAAR GLVE KVRQ LLEA GADP NGVN RFGR RAIQ VMMM GSAR VAEL LLLH GAEP NCAD PATL TRPV HDAA REGF LDTL VVLH RAGA RLDV RDAW GRLP VDLA EERG HRDV AGYL RTAT GD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | P15; MTS2; TP15; CDK4I; INK4B; p15INK4b; CDKN2B |
Positive Sample: | 293T,THP-1(negative),Mouse small intestine,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 15kDa |
Observed MW: | 15kDa/ |
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Purification Method: | Affinity purification |
Gene ID: | 1030 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |