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CDKN2A/p16INK4a Monoclonal Antibody

SKU:
CAB23450
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$167 - $635
Frequently bought together:

Description

CDKN2A/p16INK4a Monoclonal Antibody (CAB23450)

The CDKN2A p16INK4a Monoclonal Antibody is a highly specific antibody designed for research involving the CDKN2A gene, a tumor suppressor gene that encodes the p16INK4a protein. This antibody, generated in mice, is suitable for use in various experimental applications, including immunohistochemistry, immunofluorescence, and flow cytometry.The CDKN2A gene is known for its role in cell cycle regulation and inhibition of cell proliferation, making it a crucial target for cancer research. The p16INK4a protein specifically inhibits the activity of cyclin-dependent kinases, which are involved in cell cycle progression.

Dysregulation of this gene can lead to uncontrolled cell growth and contribute to the development of various types of cancer.With its high specificity and sensitivity, the CDKN2A p16INK4a Monoclonal Antibody enables precise detection and analysis of the p16INK4a protein in various biological samples. Researchers can use this antibody to better understand the mechanisms underlying tumor suppression and explore potential therapeutic strategies targeting the CDKN2A gene in cancer treatment.

Product Name:CDKN2A/p16INK4a Monoclonal Antibody
Product Code:CAB23450
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC51033
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa, 293T
Cellular Location:Cytoplasm, Nucleus

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Immunogen:Recombinant protein of human CDKN2A/p16INK4a.
Sequence:Email for sequence
Synonyms:ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A, P16-INK4A
Calculated MW:8kDa/11kDa/12kDa/13kDa/16kDa/17kDa
Observed MW:16kDa

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