The CDKN1C (p57 Kip2) Rabbit Monoclonal Antibody (CAB6843) is a valuable tool for researchers studying the CDKN1C gene, which plays a key role in cell cycle regulation and tumor suppression. This antibody, produced in rabbits, is specifically designed for use in various research applications, including immunohistochemistry, immunofluorescence, and Western blot.CDKN1C, also known as p57 Kip2, is a cyclin-dependent kinase inhibitor that functions as a tumor suppressor by halting cell cycle progression. Dysregulation of CDKN1C has been implicated in various cancers, making it a promising target for therapeutic interventions.
The high specificity and sensitivity of the CAB6843 antibody make it an essential tool for studying the expression and function of CDKN1C in cancer biology and cell cycle control.Researchers can rely on the CAB6843 antibody to accurately detect and analyze CDKN1C protein levels in various cell types and tissues, providing valuable insights into its role in cancer development and progression. By understanding the mechanisms underlying CDKN1C-mediated tumor suppression, researchers can potentially develop targeted therapies for cancer treatment.
Product Name:
CDKN1C/p57 Kip2 Rabbit Monoclonal Antibody
SKU:
CAB6843
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CDKN1C/p57 Kip2 (P49918).
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1028
Clone Number:
ARC1424
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CDKN1C/p57 Kip2 Rabbit mAb (CAB6843) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
