The CDKN1C Polyclonal Antibody (CAB2060) is a valuable tool for researchers studying CDKN1C, a protein involved in cell cycle regulation and tumor suppression. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds specifically to the CDKN1C protein, allowing for precise detection and analysis in a variety of cell types.CDKN1C, also known as p57 or KIP2, is a key player in controlling cell proliferation and differentiation, making it a crucial target for cancer research. Dysregulation of CDKN1C has been linked to various types of cancer, highlighting its importance as a potential therapeutic target.
By studying the role of CDKN1C in cell cycle control, researchers can gain valuable insights into tumor development and potentially identify new strategies for cancer treatment.Overall, the CDKN1C Polyclonal Antibody (CAB2060) is an essential tool for investigating the functions and dysregulation of CDKN1C in various cellular processes, particularly in the context of cancer research. Its high specificity and reliability make it a valuable asset for any laboratory studying cell cycle regulation and tumor suppression mechanisms.
Product Name:
CDKN1C/p57 Kip2 Rabbit Polyclonal Antibody
SKU:
CAB2060
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-107 of human CDKN1C/p57 Kip2 (NP_000067.1).
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1028
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CDKN1C/p57 Kip2 antibody (CAB2060) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
