The CDKN1B Polyclonal Antibody (CAB16722) is a valuable tool for researchers studying the CDKN1B protein, also known as p27 Kip1. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to the CDKN1B protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for research in cell cycle regulation, cancer biology, and aging.CDKN1B is a crucial regulator of cell cycle progression, functioning as a tumor suppressor by inhibiting cell proliferation.
Dysregulation of CDKN1B has been implicated in various cancers and other pathological conditions, making it an attractive target for therapeutic interventions. Research into the mechanisms of CDKN1B activity is essential for developing novel treatments for cancer and other diseases related to cell cycle dysregulation.In summary, the CDKN1B Polyclonal Antibody (CAB16722) is a reliable tool for investigating the role of CDKN1B in cellular processes and diseases, providing valuable insights for the development of targeted therapies.
Product Name:
CDKN1B/p27KIP1 Rabbit Polyclonal Antibody
SKU:
CAB16722
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CDKN1B/p27KIP1 (NP_004055.1).
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
Purification Method:
Affinity purification
Gene ID:
1027
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CDKN1B/p27KIP1 Rabbit pAb (CAB16722) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
