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CDKN1B Monoclonal Antibody [PAT7B9AT] (CPAB0238)

SKU:
CPAB0238
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT7B9AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

CDKN1B Monoclonal Antibody [PAT7B9AT] (CPAB0238)

The CDKN1B Polyclonal Antibody (CPAB0238) is a vital tool for researchers studying CDKN1B, a crucial cell cycle regulator involved in controlling cell proliferation and cell growth. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the CDKN1B protein, this antibody enables precise detection and analysis in a variety of cell types, making it an indispensable resource for studies in cancer biology and cell cycle regulation.

CDKN1B, also known as p27, acts as a tumor suppressor by inhibiting cyclin-dependent kinase activity and mediating cell cycle arrest. Dysregulation of CDKN1B has been implicated in the development and progression of various cancers, highlighting its importance as a molecular target for therapeutic interventions. Understanding the function of CDKN1B is essential for developing novel treatment strategies aimed at controlling cell proliferation and promoting apoptosis in cancer cells.

Product Name:CDKN1B Antibody
Product Sku:CPAB0238
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CDKN1B mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CDKN1B amino acids 1-198 purified from Ecoli.
Clone:PAT7B9AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:CDKN1B antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:Cyclin-dependent kinase inhibitor 1B (CDKN1B) is a member of the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The CDKN1B protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and so controls the cell cycle progression at G1. CDKN1B is often referred to as a cell cycle inhibitor protein since its major function is to stop or slow down the cell division cycle. The degradation of the CDKN1B protein, which is triggered by its CDK dependent phosphorylation and ensuing ubiquitination by SCF complexes, is compulsory for the cellular transition from inactive to the proliferative state.
Synonyms:Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1, MEN4, CDKN4, MEN1B.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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