The CDKN1A Polyclonal Antibody (CAB11454) is a valuable tool for researchers studying the role of CDKN1A, a key cell cycle regulator and tumor suppressor protein. This antibody, produced in rabbits, shows high specificity and sensitivity for human samples, making it ideal for Western blot applications. By binding to the CDKN1A protein, this antibody allows for accurate detection and analysis in various cell types.CDKN1A, also known as p21, is a crucial player in cell cycle regulation, DNA damage response, and cellular aging processes. Dysregulation of CDKN1A has been implicated in various cancers, making it an important target for cancer research and drug development.
By understanding the mechanisms and functions of CDKN1A, researchers can uncover new insights into cancer biology and potential therapeutic strategies.Overall, the CDKN1A Polyclonal Antibody (CAB11454) is a powerful tool for investigating the function and regulation of CDKN1A in both normal and disease states, providing valuable insights into cell cycle control, tumor suppression, and potential therapeutic targets in cancer research.
Product Name:
CDKN1A/p21CIP1 Rabbit Polyclonal Antibody
SKU:
CAB11454
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human CDKN1A/p21CIP1 (NP_001207707.1).
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1026
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of CDKN1A/p21CIP1 in paraffin-embedded mouse liver tissue using CDKN1A/p21CIP1 Rabbit pAb (CAB11454) at a dilution of 1:100 (40x lens). Microwave antigen retrieval was performed with 0.01 M PBS buffer (pH 7.2±0.2) prior to IHC staining.
