CDKN1A/p21CIP1 Polyclonal Antibody (CAB21772)
- SKU:
- CAB21772
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | CDKN1A/p21CIP1 Polyclonal Antibody |
| Product Code: | CAB21772 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, MCF7 |
| Cellular Location: | Cytoplasm, Nucleus |
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human CDKN1A/p21CIP1 (NP_000380.1). |
| Sequence: | MSEPA GDVRQ NPCGS KACRR LFGPV DSEQL SRDCD ALMAG CIQEA RERWN FDFVT ETPLE GDFAW ERVRG LGLPK LYLPT GPRRG RDELG GGRRP GTSPA LLQGT AEEDH VDLSL SCTLV PRSGE QAEGS PGGPG DSQGR KRRQT SMTDF YHSKR RLIFS KRKP |
| Synonyms: | P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1 |
| Calculated MW: | 18kDa |
| Observed MW: | 21kDa |
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CDKN1A/p21CIP1 Polyclonal Antibody (CAB21323)
