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CDKN1A/p21CIP1 Polyclonal Antibody (CAB21772)

SKU:
CAB21772
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
Frequently bought together:

Description

CDKN1A/p21CIP1 Polyclonal Antibody (CAB21772)

The CDKN1A (p21/Cip1) Polyclonal Antibody (CAB21772) is a powerful tool for researchers studying the CDKN1A protein, a crucial regulator of cell cycle progression and cellular response to stress. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting CDKN1A in human samples, making it ideal for use in Western blot applications.CDKN1A, also known as p21/Cip1, is a well-known tumor suppressor that functions by inhibiting the activity of cyclin-dependent kinases, leading to cell cycle arrest and apoptosis. Dysregulation of CDKN1A has been implicated in various human cancers, highlighting its importance as a target for therapeutic intervention.

By using the CDKN1A Polyclonal Antibody (CAB21772), researchers can accurately detect and analyze CDKN1A expression levels in different cell types, providing valuable insights into the molecular mechanisms underlying cell cycle control and tumorigenesis. This antibody is a valuable resource for studies in oncology, cell biology, and drug development, contributing to advancements in cancer research and personalized medicine.

Product Name:CDKN1A/p21CIP1 Polyclonal Antibody
Product Code:CAB21772
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa, MCF7
Cellular Location:Cytoplasm, Nucleus

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human CDKN1A/p21CIP1 (NP_000380.1).
Sequence:MSEPA GDVRQ NPCGS KACRR LFGPV DSEQL SRDCD ALMAG CIQEA RERWN FDFVT ETPLE GDFAW ERVRG LGLPK LYLPT GPRRG RDELG GGRRP GTSPA LLQGT AEEDH VDLSL SCTLV PRSGE QAEGS PGGPG DSQGR KRRQT SMTDF YHSKR RLIFS KRKP
Synonyms:P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1
Calculated MW:18kDa
Observed MW:21kDa

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