The CDKN1A (p21cip1) Polyclonal Antibody (CAB21323) is a valuable tool for researchers studying the CDKN1A (p21cip1) protein, which is known for its role in cell cycle regulation and tumor suppression. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CDKN1A (p21cip1) protein, this antibody allows for the detection and analysis of this important molecule in a variety of cell types.The CDKN1A (p21cip1) protein, also known as p21, is a critical regulator of cell cycle progression, acting as a potent inhibitor of cyclin-dependent kinases.
Dysregulation of CDKN1A (p21cip1) has been implicated in various diseases, including cancer, making it a key target for research in oncology and cell biology. Understanding the function and regulation of CDKN1A (p21cip1) is essential for developing targeted therapies that can manipulate cell cycle progression and potentially treat cancer and other related conditions.The CDKN1A (p21cip1) Polyclonal Antibody (CAB21323) offers researchers a reliable tool for studying the role of CDKN1A (p21cip1) in cellular processes and disease pathology, providing valuable insights that may lead to the development of novel therapeutic strategies.
Product Name:
CDKN1A/p21CIP1 Polyclonal Antibody
SKU:
CAB21323
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human CDKN1A/p21CIP1 (NP_000380.1).
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1026
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human liver using CDKN1A/p21CIP1 Rabbit pAb (CAB21323) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
