The CDKL5 Polyclonal Antibody (PAC061911) is a valuable tool for researchers studying the CDKL5 gene, which is associated with neurodevelopmental disorders. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for Western blot applications. By specifically binding to CDKL5 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in neuroscience and genetic disorders.CDKL5 is a serine/threonine kinase that plays a vital role in brain development and function. Mutations in the CDKL5 gene have been linked to severe neurodevelopmental disorders such as atypical Rett syndrome.
By studying CDKL5 and its functions, researchers aim to better understand the molecular mechanisms underlying these disorders and develop potential treatments.The CDKL5 Polyclonal Antibody (PAC061911) provides a reliable tool for investigating CDKL5 expression and activity, offering new insights into the pathophysiology of neurodevelopmental disorders. Its specificity and sensitivity make it a valuable asset for exploring the role of CDKL5 in neuronal development and synaptic function, paving the way for advancements in therapeutic strategies for individuals affected by CDKL5-related disorders.
Antibody Name:
CDKL5 Antibody (PACO61911)
Antibody SKU:
PACO61911
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human, Rat
Immunogen:
Recombinant Human Cyclin-dependent kinase-like 5 protein (790-921AA)
CDKL5: a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.Protein type: Protein kinase, CMGC; Kinase, protein; EC 2.7.11.22; Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDKL familyChromosomal Location of Human Ortholog: Xp22Cellular Component: cytoplasm; dendrite cytoplasm; nucleoplasm; nucleusMolecular Function: ATP binding; kinase activity; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase bindingBiological Process: neuron migration; positive regulation of axon extension; positive regulation of dendrite morphogenesis; positive regulation of GTPase activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of dendrite developmentDisease: Angelman Syndrome; Epileptic Encephalopathy, Early Infantile, 2
UniProt Protein Details:
NCBI Summary:
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
