The CDK8 Rabbit Monoclonal Antibody (CAB9654) is a cutting-edge research tool designed for studying CDK8, a key regulator of gene transcription and cell growth. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting CDK8 in human samples, making it a valuable asset in research on cell signaling pathways and oncogenesis. Validated for use in Western blot applications, this antibody enables precise detection and quantification of CDK8 protein levels in various cell types, facilitating insights into its role in cancer biology and other diseases.
CDK8, a member of the cyclin-dependent kinase family, is involved in modulating the activity of transcription factors and promoting cell proliferation. Dysregulation of CDK8 has been implicated in various cancers and developmental disorders, underscoring its importance as a therapeutic target. By investigating the function of CDK8 using this antibody, researchers can gain a deeper understanding of its molecular mechanisms and explore potential avenues for targeted therapies in cancer treatment and precision medicine.
Product Name:
CDK8 Rabbit Monoclonal Antibody
SKU:
CAB9654
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CDK8 (P49336).
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1024
Clone Number:
ARC1682
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CDK8 Rabbit mAb (CAB9654) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
