The CDK7 Polyclonal Antibody (CAB12942) is a valuable tool for researchers studying cyclin-dependent kinase 7 (CDK7), a key regulator of cell cycle progression and transcription. This antibody, generated in rabbits, demonstrates high specificity and sensitivity in detecting CDK7 in human samples, making it ideal for use in Western blot experiments. By targeting CDK7, researchers can gain insights into its role in controlling cell growth and gene expression, crucial for understanding cancer development and identifying potential therapeutic targets.
CDK7 is a critical component of the cell cycle machinery, playing a pivotal role in regulating the transition from G1 to S phase and facilitating RNA polymerase II-mediated transcription. Dysregulation of CDK7 has been linked to various cancers, making it a promising target for anti-cancer drug development. The CDK7 Polyclonal Antibody enables researchers to investigate the expression levels and activity of CDK7 in various cellular contexts, paving the way for new discoveries in cancer biology and personalized medicine.
Product Name:
CDK7 Rabbit Polyclonal Antibody
SKU:
CAB12942
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 211-346 of human CDK7 (NP_001790.1).
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
Purification Method:
Affinity purification
Gene ID:
1022
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] CDK7 Rabbit pAb (CAB12942) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
