The CDK7 Polyclonal Antibody (CAB12941) is intended for use in research involving CDK7, a protein kinase that plays a crucial role in regulating cell cycle progression and transcription. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding to the CDK7 protein, it allows for the detection and analysis of CDK7 expression in various cell types, making it a valuable tool for studies in molecular biology and cancer research.
CDK7 is a key regulator of cell division and gene transcription, making it a target of interest in understanding the mechanisms underlying cancer development and progression. Its function in controlling the activity of transcription factors and RNA polymerase has implications for the development of targeted therapies for cancer and other diseases. Further research into the role of CDK7 may lead to new insights into the molecular pathways involved in oncogenesis and potential strategies for therapeutic intervention.
Product Name:
CDK7 Rabbit Polyclonal Antibody
SKU:
CAB12941
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 211-346 of human CDK7 (NP_001790.1).
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
Purification Method:
Affinity purification
Gene ID:
1022
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CDK7 antibody (CAB12941) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10min.
