CDK6 Rabbit Polyclonal Antibody (CAB16357)
- SKU:
- CAB16357
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | CDK6 Rabbit Polyclonal Antibody |
SKU: | CAB16357 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human CDK6 (NP_001250.1). |
Sequence: | MEKD GLCR ADQQ YECV AEIG EGAY GKVF KARD LKNG GRFV ALKR VRVQ TGEE GMPL STIR EVAV LRHL ETFE HPNV VRLF DVCT VSRT DRET KLTL VFEH VDQD LTTY LDKV PEPG VPTE TIKD MMFQ LLRG LDFL HSHR VVHR DLKP QNIL VTSS GQIK LADF GLAR IYSF QMAL TSVV VTLW YRAP EVLL QSSY ATPV DLWS VGCI FAEM FRRK PLFR GSSD VDQL GKIL DVIG LPGE EDWP RDVA LPRQ AFHS KSAQ PIEK FVTD IDEL GKDL LLKC LTFN PAKR ISAY SALS HPYF QDLE RCKE NLDS HLPP SQNT SELN TA |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | MCPH12; PLSTIRE; CDK6 |
Positive Sample: | HeLa,Jurkat,K-562 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, ruffle. |
Calculated MW: | 37kDa |
Observed MW: | 37kDa |
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly.
Purification Method: | Affinity purification |
Gene ID: | 1021 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |