The CDK6 Rabbit Monoclonal Antibody is a highly specific research tool designed for the study of CDK6, a key regulator of cell cycle progression and proliferation. This antibody, produced in rabbits, exhibits exceptional reactivity with human samples and has been validated for use in Western blot, immunohistochemistry, and flow cytometry applications.CDK6 is a crucial player in the regulation of cell division and is often dysregulated in cancer, making it a promising therapeutic target for cancer treatment. By targeting CDK6, researchers can better understand the mechanisms underlying cell cycle control and potentially develop new strategies for cancer therapy.
The CDK6 Rabbit Monoclonal Antibody enables precise detection and analysis of CDK6 expression in various cell types, facilitating research in oncology and cell biology.Overall, the CDK6 Rabbit Monoclonal Antibody offers exceptional sensitivity and specificity for the detection of CDK6 protein, making it an invaluable tool for researchers investigating cell cycle regulation, cancer biology, and therapeutic development.
Product Name:
CDK6 Rabbit Monoclonal Antibody
SKU:
CAB0106
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 227-326 of human CDK6 (Q00534).
Cell projection, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, ruffle.
Calculated MW:
37kDa
Observed MW:
37kDa
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly.
Purification Method:
Affinity purification
Gene ID:
1021
Clone Number:
ARC0224
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CDK6 Rabbit mAb (CAB0106) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
