CDK5R1 Rabbit Polyclonal Antibody (CAB14497)
- SKU:
- CAB14497
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | CDK5R1 Rabbit Polyclonal Antibody |
SKU: | CAB14497 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 99-307 of human CDK5R1 (NP_003876.1). |
Sequence: | AQPP PAQP PAPP ASQL SGSQ TGGS SSVK KAPH PAVT SAGT PKRV IVQA STSE LLRC LGEF LCRR CYRL KHLS PTDP VLWL RSVD RSLL LQGW QDQG FITP ANVV FLYM LCRD VISS EVGS DHEL QAVL LTCL YLSY SYMG NEIS YPLK PFLV ESCK EAFW DRCL SVIN LMSS KMLQ INAD PHYF TQVF SDLK NESG QEDK KRLL LGLD R |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a; CDK5R1 |
Positive Sample: | SH-SY5Y,HeLa(negative),Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Cytoplasmic side, Lipid-anchor, Nucleus, perinuclear region. |
Calculated MW: | 34kDa |
Observed MW: | 25kDa |
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Purification Method: | Affinity purification |
Gene ID: | 8851 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |