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CDK4 Monoclonal Antibody [P6D10AT] (CPAB0170)

SKU:
CPAB0170
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
P6D10AT
$179
Frequently bought together:

Description

system_update_alt Datasheet

CDK4 Monoclonal Antibody [P6D10AT] (CPAB0170)

The CDK4 Polyclonal Antibody (CPAB0170) is a valuable tool for researchers studying CDK4, a key regulator of cell cycle progression and proliferation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications. By specifically binding to the CDK4 protein, this antibody enables the detection and analysis of CDK4 expression in various cell types, making it ideal for studies in cancer biology and cell cycle regulation.CDK4, a member of the cyclin-dependent kinase family, plays a crucial role in controlling cell division and proliferation by phosphorylating key substrates involved in cell cycle progression.

Dysregulation of CDK4 activity has been implicated in various cancers, making it a promising target for cancer therapy. By understanding the function and regulation of CDK4, researchers can develop novel strategies to target this protein for therapeutic intervention in cancer and other diseases related to cell cycle dysregulation.

Product Name:CDK4 Antibody
Product Sku:CPAB0170
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CDK4 mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CDK4 amino acids 1-33 purified from Ecoli.
Clone:P6D10AT.
Reactivity:Human
Applications:
Purification Method:CDK4 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:Cyclin-dependent kinase 4 combines with the protein cyclin D to form a protein complex that promotes the passage of cells through the G1 checkpoint in the cell growth cycle. This cellular activity is regulated by the protein p16 produced by p16INK4a. Normally, p16 controls cell growth by inhibiting the activity of the CDK4€“cyclin D complex and stopping cells at the G1 checkpoint.
Synonyms:Cell division protein kinase 4, CDK4, EC 2.7.11.22, Cyclin-dependent kinase 4, PSK-J3, CMM3, CDK-4, MGC14458.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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