The CDK12 Polyclonal Antibody (CAB14894) is a valuable tool for researchers studying CDK12, a key protein involved in cellular processes such as transcription regulation and DNA repair. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CDK12 protein, this antibody enables accurate detection and analysis of CDK12 in various cell types, making it an essential reagent for studies in cancer research and beyond.
CDK12 is a critical player in cell cycle regulation and gene expression, making it a promising target for therapeutic interventions in diseases such as cancer. Dysregulation of CDK12 has been linked to tumor formation and progression, making it an important focus for research aimed at developing new treatments. By understanding the role of CDK12 in cellular processes, researchers can potentially identify new strategies for targeting cancer cells and improving patient outcomes.
Product Name:
CDK12 Rabbit Polyclonal Antibody
SKU:
CAB14894
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CDK12 (NP_057591.2).
Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex.
Purification Method:
Affinity purification
Gene ID:
51755
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from LNCaP cells, using CDK12 Rabbit pAb (CAB14894) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
