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CDK12 Rabbit Polyclonal Antibody (CAB14894)

SKU:
CAB14894
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:CDK12 Rabbit Polyclonal Antibody
SKU:CAB14894
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CDK12 (NP_057591.2).
Sequence:MPNS ERHG GKKD GSGG ASGT LQPS SGGG SSNS RERH RLVS KHKR HKSK HSKD MGLV TPEA ASLG TVIK PLVE YDDI SSDS DTFS DDMA FKLD RREN DERR GSDR SDRL HKHR HHQH RRSR DLLK AKQT EKEK SQEV SSKS GSMK DRIS GSSK RSNE ETDD YGKA QVAK SSSK ESRS SKLH KEKT RKER ELKS GHKD RSKS HRKR ETPK SYKT VDSP KRRS RSPH RKWS DSSK QDDS PSGA SYGQ DYDL SPSR SHTS SNYD SYKK SPGS TSRR QSVS PPYK EPSA YQSS TRSP SPYS RRQR
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:100 - 1:500
Synonyms:CRK7; CRKR; CRKRS; CDK12
Positive Sample:LNCaP,Mouse brain
Conjugate:Unconjugated
Cellular Localization:Nucleus, Nucleus speckle.
Calculated MW:164kDa
Observed MW:205kDa

Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex.

Purification Method:Affinity purification
Gene ID:51755
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from LNCaP cells, using CDK12 Rabbit pAb (CAB14894) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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