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CDK1 Polyclonal Antibody

SKU:
CAB21725
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IP
IF
$155 - $431
Frequently bought together:

Description

CDK1 Polyclonal Antibody (CAB21725)

The CDK1 Polyclonal Antibody is a valuable tool for researchers interested in studying the cell division cycle protein kinase 1 (CDK1), a key regulator of cell cycle progression. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot experiments. By targeting the CDK1 protein, this antibody allows for the detection and analysis of CDK1 in various cell types, making it ideal for studies in cell biology and cancer research.CDK1 plays a critical role in regulating the timing of cell division and ensuring accurate chromosome segregation during mitosis.

Dysregulation of CDK1 activity has been implicated in various diseases, including cancer, making it a promising target for therapeutic intervention. By studying the function of CDK1 using this antibody, researchers can gain valuable insights into the mechanisms underlying cell cycle control and potential avenues for the development of novel anti-cancer therapies.

Product Name:CDK1 Polyclonal Antibody
Product Code:CAB21725
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunoprecipitation, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, IP, ELISA
Key Applications:Western blotting, Immunoprecipitation, Immunofluorescence
Recommended Dilution:WB 1:500-1:1000, IP 1:500-1:1000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Positive Samples:MCF7, Jurkat, C6, Mouse kidney, Mouse spleen
Cellular Location:Cytoplasm, Mitochondrion, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 198-297 of human CDK1 (NP_001777.1).
Sequence:ATKKP LFHGD SEIDQ LFRIF RALGT PNNEV WPEVE SLQDY KNTFP KWKPG SLASH VKNLD ENGLD LLSKM LIYDP AKRIS GKMAL NHPYF NDLDN QIKKM
Synonyms:CDC2, CDC28A, P34CDC2
Calculated MW:34kDa
Observed MW:34kDa

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