Anti-CDH8 Antibody (CAB16812)

Antibody Name:	Anti-CDH8 Antibody
Antibody SKU:	CAB16812
Antibody Size:	20uL, 50 uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 500-610 of human CDH8 (NP_001787.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 500-610 of human CDH8 (NP_001787.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	YEAF LCEN GKPG QVIQ TVSA MDKD DPKN GHYF LYSL LPEM VNNP NFTI KKNE DNSL SILA KHNG FNRQ KQEV YLLP IIIS DSGN PPLS STST LTIR VCGC SNDG VVQS CNV
Gene ID:	1006
Uniprot:	P55286
Cellular Location:
Calculated MW:	88kDa
Observed MW:	Refer to figures

Synonyms:

CDH8, Nbla04261

Background:

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.

UniProt Protein Function:	CDH8: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
UniProt Protein Details:	Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: plasma membrane Biological Process: cell adhesion
NCBI Summary:	This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]
UniProt Code:	P55286
NCBI GenInfo Identifier:	13432121
NCBI Gene ID:	1006
NCBI Accession:	P55286.2
UniProt Secondary Accession:	P55286,Q14DC6, Q9ULB2, B3KWC1,
UniProt Related Accession:	P55286
Molecular Weight:	88,253 Da
NCBI Full Name:	Cadherin-8
NCBI Synonym Full Names:	cadherin 8
NCBI Official Symbol:	CDH8
NCBI Official Synonym Symbols:	Nbla04261
NCBI Protein Information:	cadherin-8
UniProt Protein Name:	Cadherin-8
Protein Family:	Cadherin
UniProt Gene Name:	CDH8
UniProt Entry Name:	CADH8_HUMAN

Antibodies

Anti-CDH8 Antibody (CAB14236)

CDH8 Antibody (PACO02292)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)