The CDH5 Polyclonal Antibody (CAB12416) is a valuable tool for researchers studying CDH5, also known as VE-cadherin. This cell adhesion molecule plays a critical role in vascular development and maintenance, making it a key player in angiogenesis and endothelial cell function. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. It specifically binds to the CDH5 protein, enabling precise detection and analysis in various cell types and tissues. Research involving CDH5 is essential for understanding the mechanisms underlying vascular development, as well as for studying diseases such as cancer, cardiovascular disorders, and inflammatory conditions.
By targeting CDH5, researchers can explore new therapeutic avenues for treating conditions related to abnormal blood vessel formation and function. Overall, the CDH5 Polyclonal Antibody (CAB12416) is a valuable tool for researchers interested in unraveling the complex roles of CDH5 in vascular biology and disease pathogenesis.
Product Name:
CDH5 Rabbit Polyclonal Antibody
SKU:
CAB12416
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 621-784 of human VE Cadherin (NP_001786.2).
Cell junction, Cell membrane, Single-pass type I membrane protein.
Calculated MW:
88kDa
Observed MW:
140kDa
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer.
Purification Method:
Affinity purification
Gene ID:
1003
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using VE Cadherin Rabbit pAb (CAB12416) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
