The CDH22 Polyclonal Antibody (PACO05034) is specifically designed for research involving CDH22, a cell surface molecule implicated in neuronal development and synaptic plasticity. The antibody, produced in rabbits, is highly sensitive and specific for detecting CDH22 in various experimental settings. It has been validated for use in applications such as immunofluorescence and flow cytometry, allowing for accurate and reliable detection of CDH22 in neuronal tissues and cell cultures.CDH22, also known as cadherin 22, is involved in the regulation of cell-cell adhesion and is crucial for the formation and maintenance of synaptic connections in the brain. Studies have shown that dysregulation of CDH22 expression is associated with neurodevelopmental disorders and cognitive impairments.
By targeting CDH22 with this antibody, researchers can investigate its role in synaptic function and potentially develop new therapeutic strategies for neurological conditions.This CDH22 Polyclonal Antibody is a valuable tool for researchers interested in studying the molecular mechanisms underlying neuronal development and synaptic plasticity. Its high specificity and sensitivity make it an ideal choice for experiments aimed at understanding the function of CDH22 in normal brain development and in neurological disorders.
Synthesized peptide derived from the Internal region of human Cadherin-22.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CDH22; C20orf25; Cadherin-22; Pituitary and brain cadherin; PB-cadherin
UniProt Protein Function:
CDH22: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 20q13.1Cellular Component: integral to membrane; plasma membraneMolecular Function: calcium ion bindingBiological Process: calcium-dependent cell-cell adhesion; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs. [provided by RefSeq, Jul 2008]
