The Cadherin-11 Polyclonal Antibody (CAB12176) is specially designed for research involving Cadherin-11, a cell adhesion molecule known for its role in cell-cell adhesion and migration. This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Cadherin-11 protein, this antibody enables accurate detection and analysis in various cell types, making it an excellent choice for studies in developmental biology and cancer research.Cadherin-11, a member of the cadherin superfamily, plays a crucial role in various biological processes, including tissue morphogenesis and tumor metastasis.
Its involvement in cell-cell adhesion and migration makes it a key target for research in fields such as developmental biology and cancer biology. Understanding the function and regulation of Cadherin-11 is essential for unraveling its impact on cellular processes and identifying potential therapeutic interventions in conditions like cancer and developmental disorders.This Cadherin-11 Polyclonal Antibody (CAB12176) provides researchers with a valuable tool for studying the role of Cadherin-11 in cellular processes and disease states, offering insights that could lead to the development of novel therapeutic approaches targeting Cadherin-11
Product Name:
CDH11 Rabbit Polyclonal Antibody
SKU:
CAB12176
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human CDH11 (NP_001788.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
88kDa
Observed MW:
110kDa
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
Purification Method:
Affinity purification
Gene ID:
1009
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CDH11 Rabbit pAb (CAB12176) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
