The CDCA8 Polyclonal Antibody (CAB15463) is a valuable tool for researchers investigating the role of CDCA8 in cellular processes such as cell division and DNA repair. CDCA8, also known as Borealin, is a key component of the chromosomal passenger complex, essential for proper chromosome segregation during mitosis.This polyclonal antibody, produced in rabbits, is highly specific to human CDCA8 and has been validated for use in Western blot applications. Its high reactivity and specificity make it an ideal choice for studying CDCA8 expression and localization in various cell types.
Research on CDCA8 is important for understanding its functions in cell cycle regulation and genome stability, as dysregulation of CDCA8 expression has been linked to cancer and other diseases. By using this antibody, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially discover new therapeutic targets for diseases characterized by abnormal cell division and DNA damage.
Product Name:
CDCA8 Rabbit Polyclonal Antibody
SKU:
CAB15463
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human CDCA8 (NP_060571.1).
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16.
Purification Method:
Affinity purification
Gene ID:
55143
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CDCA8 Rabbit pAb (CAB15463) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
