UniProt Protein Function: | CDCA7: Participates in MYC-mediated cell transformation; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 2q31Cellular Component: nucleoplasm; cytoplasm; nucleusBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; regulation of cell proliferation |
UniProt Protein Details: | |
NCBI Summary: | This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BWT1 |
NCBI GenInfo Identifier: | 88999586 |
NCBI Gene ID: | 83879 |
NCBI Accession: | NP_114148.3 |
UniProt Secondary Accession: | Q9BWT1,Q53EW5, Q580W9, Q658K4, Q658N4, Q8NBY9, Q96BV8 Q96SP5, B4DLP8, B4DV66 |
UniProt Related Accession: | Q9BWT1 |
Molecular Weight: | 46,400 Da |
NCBI Full Name: | cell division cycle-associated protein 7 isoform 1 |
NCBI Synonym Full Names: | cell division cycle associated 7 |
NCBI Official Symbol: | CDCA7Â Â |
NCBI Official Synonym Symbols: | JPO1Â Â |
NCBI Protein Information: | cell division cycle-associated protein 7; c-Myc target JPO1; cell division cycle associated protein 7 |
UniProt Protein Name: | Cell division cycle-associated protein 7 |
UniProt Synonym Protein Names: | Protein JPO1 |
Protein Family: | Cell division cycle-associated protein |
UniProt Gene Name: | CDCA7Â Â |
UniProt Entry Name: | CDCA7_HUMAN |